02686nas a2200277   4500008004100000020001400041024001700055245012500072210006900197260031200266300001400578490000700592520152600599653001802125653002602143653002202169100001702191700002402208700001802232700002302250700001902273700001802292700002502310700002402335856004902359       2013                        eng d  a0041-1337  awej, 013214400aDonor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection:  A Prospective Single-Center Study.0 aDonor and Recipient BKVSpecific IgG Antibody and Posttransplanta  a(C) 2013 Lippincott Williams & Wilkins, Inc.b(1) Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.(2) Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.(3) Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.(4) Pediatric Nephrc2013  a896 - 9020 v953 aBackground: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection., Methods: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay >=8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (>=10,000 copies/mL plasma)., Results: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, 17 of 41, and 25 of 68 in the D+R-, D+R+, D-R+, and D-R- groups, respectively. Any viremia (20 of 41) and significant viremia (10 of 41) seen in the D+R- group was significantly higher than other groups (P=0.014). In 11 pediatric recipients, infection was seen only in the D+R- group. Overall, infection was highest in the D+R- group and lowest in the D-R- group., Conclusions: BKV serostatus can be used to risk stratify patients for posttransplantation infection., (C) 2013 Lippincott Williams & Wilkins, Inc.10aBKV infection10aBKV-specific antibody10akidney transplant1 aSood, Puneet1 aSenanayake, Shamila1 aSujeet, Kumar1 aMedipalli, Radhika1 aVan-Why, Scott1 aCronin, David1 aJohnson, Christopher1 aHariharan, Sundaram  uhttps://www.notifylibrary.org/reference/4039