02783nas a2200265   4500008004100000020001400041024001200055245018600067210006900253260028200322520159700604653001302201653002202214653002602236653003802262100002002300700001902320700002402339700002102363700002002384700002202404700002002426700002202446856004902468       2015                        eng d  a1386-6346  a971180100aRare case of transfusion-transmitted hepatitis E from the blood of a donor infected with the hepatitis E virus genotype 3 indigenous to Japan: Viral dynamics from onset to recovery.0 aRare case of transfusiontransmitted hepatitis E from the blood o  a(C) 2015 John Wiley & Sons, Ltdb(1)Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan(2)Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan(3)Japanese Red Cross Hokkaido Block Blood Center, Hokkaido, Japanc20153 aAim: The transfusion transmission of hepatitis E can occur even in non-endemic areas in the world as autochthonous hepatitis E has been increasingly reported in developed countries where the hepatitis E virus (HEV) is not prevalent. We investigated the post-transfusion transmission of hepatitis E in a patient by molecularly confirming its presence, and characterized the viral kinetics of HEV in this case., Methods: A Japanese man underwent re-thoracotomy for hemostasis followed by platelet transfusion. After the transfusion, the blood donor was found to be HEV positive. The donated blood was re-examined and was found to contain HEV. Throughout the prospective follow up of the patient, we analyzed the viral kinetics, chronological anti-HEV antibody level changes and disease progression during the entire course of HEV infection from transfusion until the end of viremia., Results: Sequence analysis of the strains isolated from both the donor and the patient who contracted acute hepatitis E showed an identical match for 326 nucleotides in open reading frame 1. Two strains belonged to HEV genotype 3 indigenous to Japan., Conclusion: To the best of our knowledge, this is the first detailed report on the entire natural course of hepatitis E from viral transmission, then clearance, to replication preceding liver injury caused by HEV genotype 3, which is responsible for autochthonous infection in developed countries. The findings provide valuable insights into the mechanism of the transfusion transmission of HEV and subsequent viral dynamics., (C) 2015 John Wiley & Sons, Ltd10aGenotype10aHepatitis E virus10ahepatitis E virus RNA10atransfusion-transmitted hepatitis1 aMatsui, Takeshi1 aKang, Jong-Hon1 aMatsubayashi, Keiji1 aYamazaki, Hajime1 aNagai, Kazumasa1 aSakata, Hidekatsu1 aTsuji, Kunihiko1 aMaguchi, Hiroyuki  uhttps://www.notifylibrary.org/reference/4072