02186nas a2200205   4500008004100000020001400041024001700055245009800072210006900170260019000239300001600429490000700445520138500452100002001837700001801857700002001875700002101895700001501916856004901931       2011                        eng d  a0041-1132  awdn, 041736000aAtopic predisposition of recipients in allergic transfusion reactions to apheresis platelets.0 aAtopic predisposition of recipients in allergic transfusion reac  aCopyright (C) 2011 Blackwell Publishing Ltd.b(1)From the Department of Pathology and the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.c2011  a2337 - 23420 v513 aBACKGROUND: The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients., STUDY DESIGN AND METHODS: We identified 37 consecutive apheresis PLT recipients who experienced an ATR and 26 matched controls. Total immunoglobulin (Ig)E and aero- and food allergen-specific IgE were quantified in plasma by a blood test for allergies (ImmunoCAP: Phadiatop and Fx5). IgE testing of apheresis PLT supernatants was also performed., RESULTS: Pruritus and urticaria were manifest in 91.9 and 83.8% of all ATRs, with more severe respiratory symptoms and angioedema occurring in less than 15% of cases. No subject had anaphylaxis. Sex, age, and primary diagnosis were balanced between the two groups. Total and aeroallergen-specific IgE was higher among subjects experiencing an ATR in comparison to control subjects (median total IgE, 55.5 kU/L vs. 8.3 kU/L, p = 0.002; and median aeroallergen-specific IgE, 0.57 kUa/L vs. 0.36 kUa/L, p = 0.046). IgE antibody levels in apheresis products associated with ATRs were similar to control products (p > 0.1 for all IgE tests)., CONCLUSION: Recipient atopic predisposition, as defined by IgE sensitization, is a risk factor associated with ATRs., Copyright (C) 2011 Blackwell Publishing Ltd.1 aSavage, William1 aTobian, Aaron1 aSavage, Jessica1 aHamilton, Robert1 aNess, Paul  uhttps://www.notifylibrary.org/reference/4120