02034nas a2200217   4500008004100000020001400041024001700055245007600072210006900148260026600217300001400483490000700497520114200504100002101646700002201667700001901689700002001708700001901728700002001747856004901767       2013                        eng d  a0041-1132  awdn, 041736000aTransfusion-transmitted anaplasmosis from leukoreduced red blood cells.0 aTransfusiontransmitted anaplasmosis from leukoreduced red blood   aCopyright (C) 2013 Blackwell Publishing Ltd.b(1) From the Blood Bank and Transfusion Medicine, the Division of Infectious Disease, The Miriam Hospital, and the Rhode Island Blood Center, Providence, Rhode Island; and Imugen, Inc., Norwood, Massachusetts.c2013  a181 - 1860 v533 aBACKGROUND: Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial infectious disease. To date four cases of transfusion-transmitted anaplasmosis (TTA) have been described in the literature, and only one from leukoreduced red blood cells (RBCs)., CASE REPORT: A 64-year-old patient with acute gastrointestinal blood loss was admitted to the hospital and received 5 units of prestorage leukoreduced RBCs. He was stabilized and discharged. He developed headache, fever, and chills 2 days after discharge and was readmitted. On Day 5 of his second admission polymorphonuclear leukocytes containing morulae consistent with HGA were reported in the peripheral smear., RESULTS: Samples from the recipient tested positive by polymerase chain reaction (PCR) for Anaplasma phagocytophilum, the causative agent of HGA and a segment from one of the five donors tested positive by both serology and PCR., CONCLUSION: Leukoreduction theoretically reduces the risk of TTA but does not interdict all infections. TTA requires consideration in recipients of RBC transfusion with unexplained fever., Copyright (C) 2013 Blackwell Publishing Ltd.1 aAlhumaidan, Hiba1 aWestley, Benjamin1 aEsteva, Carlos1 aBerardi, Victor1 aYoung, Carolyn1 aSweeney, Joseph  uhttps://www.notifylibrary.org/reference/4158