02551nas a2200301   4500008004100000020001400041024001900055245011900074210006900193260029800262300001400560490000700574520139600581653002301977653002702000653002102027100001502048700001802063700001402081700001502095700001402110700001402124700001402138700001502152700001502167700001802182856004902200       2015                        eng d  a1398-2273  ad1d, 10088368800aTransmission of infection to liver transplant recipients from donors with infective endocarditis: lessons learned.0 aTransmission of infection to liver transplant recipients from do  a(C) 2015 John Wiley & Sons A/Sb(1)Department of Internal Medicine, Division of Infectious Diseases, University of Michigan School of Medicine, Ann Arbor, Michigan, USA(2)Department of Internal Medicine, Division of Infectious Diseases, Henry Ford Health System, Detroit, Michigan, USA(3c2015  a140 - 1460 v173 a: Donors not meeting standard criteria, such as those with bacteremia, are now being used in response to the increasing need for organs for transplantation. Recommended strategies to prevent the occurrence of donor-derived bacteremia include the use of directed antibiotic prophylaxis. However, this approach does not eliminate the risk of infection transmission. Similarly, the management of organ recipients from donors with infective endocarditis (IE) remains uncharacterized. We report 2 cases of donor-derived bacterial infections in liver transplant recipients despite pathogen-specific antibiotic prophylaxis. In both instances, the donors had documented IE treated with appropriate antimicrobial therapy and clearance of bacteremia. Recipients had very distinctive clinical outcomes likely related to pathogen virulence and the extent of donor infection. Persistent infection in the transplanted liver should be suspected in organ recipients of a liver from donors with IE, despite the absence of bacteremia at the time of death and organ procurement. For eradication, recipients may require prolonged pathogen-directed antimicrobial therapy, such as is used for endovascular infections. Prompt recognition of donors with IE, appropriate notification, and prolonged antibiotic prophylaxis are key to reducing the risk of such donor-derived infections., (C) 2015 John Wiley & Sons A/S10adonor transmission10ainfective endocarditis10aliver transplant1 aMiceli, M.1 aGonulalan, M.1 aPerri, M.1 aSamuel, L.1 aFares, Al1 aBrown, K.1 aBruno, D.1 aZervos, M.1 aRamesh, M.1 aAlangaden, G.  uhttps://www.notifylibrary.org/reference/4162