02902nas a2200229   4500008004100000020001400041024001700055245013500072210006900207260031200276300001400588490000700602520187900609100001602488700002002504700002002524700002302544700002302567700001502590700001802605856004902623       2011                        eng d  a0041-1132  awdn, 041736000aIncidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients.0 aIncidence and transfusion risk factors for transfusionassociated  aCopyright (C) 2011 Blackwell Publishing Ltd.b(1) From the Division of Pulmonary and Critical Care Medicine, Mayo Epidemiology and Translational Research in Intensive Care (M.E.T.R.I.C), the Division of Critical Care Medicine, Department of Anesthesiology, and the Division of Biomedical Informatics ac2011  a338 - 3430 v513 aBACKGROUND: Transfusion-associated circulatory overload (TACO) is a frequent complication of blood transfusion. Investigations identifying risk factors for TACO in critically ill patients are lacking., STUDY DESIGN AND METHODS: We performed a 2-year prospective cohort study of consecutive patients receiving blood product transfusion in the medical intensive care unit (ICU) of the tertiary care institution. Patients were followed for development of transfusion-related complications. TACO was defined as acute hydrostatic pulmonary edema occurring within 6 hours of transfusion. In a nested case-control design, transfusion characteristics were compared between cases (TACO) and controls after matching by age, sex, and ICU admission diagnostic category. In a secondary analysis, patient characteristics before transfusion were compared between cases (TACO) and randomly selected controls., RESULTS: Fifty-one of 901 (6%) transfused patients developed TACO. Compared with matched controls, TACO cases had a more positive fluid balance (1.4 L vs. 0.8 L, p = 0.003), larger amount of plasma transfused (0.4 L vs. 0.07 L, p = 0.007), and faster rate of blood component transfusion (225 mL/hr vs. 168 mL/hr, p = 0.031). In a secondary analysis comparing TACO cases and random controls, left ventricular dysfunction before transfusion (odds ratio [OR], 8.23; 95% confidence interval [CI], 3.36-21.97) and plasma ordered for the reversal of anticoagulant (OR, 4.31; 95% CI, 1.45-14.30) were significantly related to the development of TACO., CONCLUSION: Volume of transfused plasma and the rate of transfusion were identified as transfusion-specific risk factors for TACO. Left ventricular dysfunction and fresh-frozen plasma ordered for the reversal of anticoagulant were strong predictors of TACO before the onset of transfusion., Copyright (C) 2011 Blackwell Publishing Ltd.1 aLi, Guangxi1 aRachmale, Sonal1 aKojicic, Marija1 aShahjehan, Khurram1 aMalinchoc, Michael1 aKor, Daryl1 aGajic, Ognjen  uhttps://www.notifylibrary.org/reference/4165