03258nas a2200337   4500008004100000020001400041024001700055245017500072210006900247260019200316300001400508490000800522520202800530653002202558653003802580653001702618653004802635100001402683700001702697700001602714700001502730700001602745700001602761700001602777700001702793700001602810700001502826700001302841700001702854856004902871       2014                        eng d  a0042-9007  axli, 041360600aTransfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during 2011.0 aTransfusionassociated circulatory overload TACO and potential ri  a(C) 2014 John Wiley & Sons, Ltdb(1)Food and Drug Administration, Rockville, MD, USA(2)Acumen LLC, Burlingame, CA, USA(3)Centers for Medicare & Medicaid Services, Baltimore, MD, USAc2014  a144 - 1520 v1063 aBackground and Objectives: Transfusion-associated circulatory overload (TACO) is a serious transfusion complication resulting in respiratory distress. The study's objective was to assess TACO occurrence and potential risk factors among elderly Medicare beneficiaries (ages 65 and older) in the inpatient setting during 2011., Materials and Methods: This retrospective claims-based study utilized Medicare administrative databases in coordination with Centers for Medicare & Medicaid Services. Transfusions were identified by recorded procedure and revenue centre codes, while TACO was ascertained via ICD-9-CM diagnosis code. We evaluated TACO diagnosis code rates overall and by age, gender, race, number of units and blood components transfused. Multivariate logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs)., Results: Among 2 147 038 inpatient transfusion stays for elderly in 2011, 1340 had TACO diagnosis code, overall rate of 62[middle dot]4 per 100 000 stays. TACO rates increased significantly with age and units transfused (P < 0[middle dot]0001). After adjustment for confounding, significantly higher odds of TACO were found for women vs. men (OR = 1[middle dot]40, 95% CI 1[middle dot]26-1[middle dot]60), White people vs. non-White people (OR = 1[middle dot]38, 95% CI 1[middle dot]20-1[middle dot]62) and persons with congestive heart failure (OR = 1[middle dot]61, 95% CI 1[middle dot]44-1[middle dot]88), chronic pulmonary disease (OR = 1[middle dot]19, 95% CI 1[middle dot]08-1[middle dot]32) and different anaemias., Conclusion: Our study identified largest number of potential TACO cases to date and showed a substantial increase in TACO occurrence with age and number of units transfused. The study suggested increased TACO risk in elderly with congestive heart failure, chronic pulmonary disease and anaemias. Overall, study shows importance of large administrative databases as an additional epidemiological tool., (C) 2014 John Wiley & Sons, Ltd10ainpatient elderly10aMedicare administrative databases10aRisk Factors10aTransfusion-Associated Circulatory Overload1 aMenis, M.1 aAnderson, S.1 aForshee, R.1 aMcKean, S.1 aJohnson, C.1 aHolness, L.1 aWarnock, R.1 aGondalia, R.1 aWorrall, C.1 aKelman, J.1 aBall, R.1 aIzurieta, H.  uhttps://www.notifylibrary.org/reference/4172