03032nas a2200313   4500008004100000020001400041024001900055245018000074210006900254260029800323300001200621490000700633520176300640653002002403653003502423653002502458653003102483100001802514700001802532700001502550700001402565700001302579700001402592700001502606700001602621700001802637700001402655856004902669       2014                        eng d  a1398-2273  ad1d, 10088368800aThree cases of donor-derived pulmonary tuberculosis in lung transplant recipients and review of 12 previously reported cases: opportunities for early diagnosis and prevention.0 aThree cases of donorderived pulmonary tuberculosis in lung trans  a(C) 2014 John Wiley & Sons A/Sb(1)Epidemic Intelligence Service Field Assignments Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA(2)Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA(3)Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, c2014  a67 - 750 v163 aIntroduction. Solid organ transplant recipients have a higher frequency of tuberculosis (TB) than the general population, with mortality rates of approximately 30%. Although donor-derived TB is reported to account for <5% of TB in solid organ transplants, the source of Mycobacterium tuberculosis infection is infrequently determined., Methods. We report 3 new cases of pulmonary TB in lung transplant recipients attributed to donor infection, and review the 12 previously reported cases to assess whether cases could have been prevented and whether any cases that might occur in the future could be detected and investigated more quickly. Specifically, we evaluate whether opportunities existed to determine TB risk on the basis of routine donor history, to expedite diagnosis through routine mycobacterial smears and cultures of respiratory specimens early post transplant, and to utilize molecular tools to investigate infection sources epidemiologically., Findings. On review, donor TB risk was present among 7 cases. Routine smears and cultures diagnosed 4 asymptomatic cases. Genotyping was used to support epidemiologic findings in 6 cases., Conclusion. Validated screening protocols, including microbiological testing and newer technologies (e.g., interferon-gamma release assays) to identify unrecognized M. tuberculosis infection in deceased donors, are warranted., E. Mortensen, W. Hellinger, C. Keller, L.S. Cowan, T. Shaw, S. Hwang, D. Pegues, S. Ahmedov, M. Salfinger, W.A. Bower. Three cases of donor-derived pulmonary tuberculosis in lung transplant recipients and review of 12 previously reported cases: opportunities for early diagnosis and prevention. Transpl Infect Dis 2014: 16: 67-75. All rights reserved, (C) 2014 John Wiley & Sons A/S10aDonor Selection10ainterferon gamma release assay10aLung Transplantation10aMycobacterium tuberculosis1 aMortensen, E.1 aHellinger, W.1 aKeller, C.1 aCowan, L.1 aShaw, T.1 aHwang, S.1 aPegues, D.1 aAhmedov, S.1 aSalfinger, M.1 aBower, W.  uhttps://www.notifylibrary.org/reference/4264