02182nas a2200253   4500008004100000020001400041245008600055210006900141260031100210300001200521490000700533520114600540100001601686700001901702700002101721700002001742700002101762700001801783700001801801700002301819700001701842700002001859856004901879       2000                        eng d  a1058-483800aEnterobacter cloacae Bloodstream Infections Traced to Contaminated Human Albumin.0 aEnterobacter cloacae Bloodstream Infections Traced to Contaminat  a(C) Copyright Oxford University Press 2000.b(1)Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia(2)Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD(3)Division of Product c2000  a35 - 400 v303 a: In August 1996, a patient in Kansas developed an Enterobacter cloacae bloodstream infection (BSI) shortly after receiving Albuminar, a brand of human albumin. Albuminar contamination was suspected. A case-control study of patients with primary gram-negative bacterial BSIs showed that patients with E. cloacae BSIs were significantly more likely than patients with non-E. cloacae gram-negative BSIs to have received Albuminar within 3 days of developing their BSIs (3 of 5 vs. 0 of 9; OR, undefined; P = .03). The E. cloacae isolate from the Kansas patient was found by pulsed-field gel electrophoresis to be identical to the isolate from the patient's Albuminar vial, to isolates from 2 previously unopened Albuminar vials, and to an isolate from a Wisconsin patient who had received Albuminar. A worldwide recall of ~116,000 Albuminar vials took place. This multistate outbreak was detected because of clinical astuteness and prompt reporting. Combined epidemiological and laboratory approaches are valuable when investigating potentially contaminated blood components and plasma derivatives., (C) Copyright Oxford University Press 2000.1 aWang, Susan1 aTokars, Jerome1 aBianchine, Peter1 aCarson, Loretta1 aArduino, Matthew1 aSmith, Arline1 aHansen, Nancy1 aFitzgerald, Edward1 aEpstein, Jay1 aJarvis, William  uhttps://www.notifylibrary.org/reference/4316