02894nas a2200337   4500008004100000020001400041024001700055245013300072210006900205260023800274300001200512490000700524520169000531653001902221653001902240653001902259653001602278653001402294653001702308100001802325700002302343700002102366700001202387700001602399700001202415700002302427700001202450700003302462700001202495856004902507       2015                        eng d  a0883-9441  abuy, 861064200aIncidence, risk factors, and outcome of transfusion-related acute lung injury in critically ill children: A retrospective study.0 aIncidence risk factors and outcome of transfusionrelated acute l  a(C) 2015Elsevier, Inc.b(a)Department of Pediatric Intensive Care, Emma Children's Hospital/Academic Medical Centre, Amsterdam, the Netherlands(b)Department of Intensive Care, Academic Medical Centre, Amsterdam, the Netherlandsc2015  a55 - 590 v303 aPurpose: Acute lung injury (ALI) that develops within 6 hours after transfusion (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both incidence and patient and transfusion-related risk factors are well studied in the adult critically ill patient population. Clinical data on TRALI in the pediatric population are sparse and are mainly limited to case reports and hemovigilance reporting systems. The objective of this study was to determine incidence, risk factors, and outcome of TRALI in critically ill children., Materials and Methods: In a retrospective cohort study, all first-time admissions to the pediatric intensive care unit from January 1, 2009, until December 31, 2012, were screened for onset of TRALI using the consensus criteria., Results: Of 2294 admitted patients, 304 were transfused, of whom 21 (6.9%) developed TRALI. Compared with transfused control subjects, risk factors for TRALI were mechanical ventilation (odds ratio, 18.94 [2.38-2452.56]), sepsis (odds ratio, 7.20 [2.69-19.69]), and high Pediatric Risk of Mortality III score (odds ratio, 1.05 [1.01-1.10]). Patients with TRALI had a higher mortality and a longer duration of mechanical ventilation when compared with transfused control subjects., Conclusions: Transfusion-related ALI is relatively common in critically ill children. The incidence in the pediatric intensive care unit population is similar to that in adult intensive care unit patients. High PRISM score on admission, mechanical ventilation and sepsis were identified as independent risk factors, which may help to assess the risks and benefits of transfusion in critically ill patients., (C) 2015Elsevier, Inc.10ablood products10aCritically ill10aIntensive Care10aLung injury10aPediatric10aTransfusions1 aMulder, Hilde1 aAugustijn, Quinten1 avan Woensel, Job1 aMD, PhD1 aBos, Albert1 aMD, PhD1 aJuffermans, Nicole1 aMD, PhD1 avan Asperen, Roelie, Wosten-1 aMD, PhD  uhttps://www.notifylibrary.org/reference/4350