TY - JOUR T1 - Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture JF - BMC Ophthalmol Y1 - 2010 A1 - Muzaliha,M. N. A1 - Adil,H. A1 - Ibrahim,M. A1 - Shatriah,I. KW - Abscess / etiology / pathology / ultrasonography KW - Administration, Topical KW - Amphotericin B / administration & dosage KW - Antifungal Agents / administration & dosage KW - Candida glabrata / *isolation & purification KW - Candidiasis / *etiology KW - Drug Administration Schedule KW - Endophthalmitis / *microbiology / pathology KW - Eye Diseases / etiology / ultrasonography KW - Fuchs' Endothelial Dystrophy / *surgery KW - Humans KW - Injections, Intraocular KW - Injections, Intravenous KW - Keratoplasty, Penetrating / *adverse effects KW - Male KW - Middle Aged KW - Sutures / adverse effects KW - Transplants / *microbiology KW - Vitreous Body / ultrasonography AB - BACKGROUND: Candida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture. CASE PRESENTATION: A 63-year-old patient, diagnosed Fuch's endothelial dystrophy in both eyes underwent a penetrating keratoplasty in his right eye. He had multiple underlying medical problems, which included diabetes mellitus, hypertension, hypoadrenalism on oral dexamethasone and fatty liver secondary to hypertrigliseridemia. He developed multiple suture abscesses, corneal haziness, retrocorneal white plaques and a level of hypopyon two weeks after an uneventful penetrating keratoplasty in his right eye. Cultures of the donor button and the transport media culture were negative. Candida glabrata was isolated successfully from the aqueous and vitreous taps. He was treated with a combination of topical, intracameral, intravitreal and intravenous Amphotericin B. His final visual acuity remained poor due to the haziness of the corneal button. CONCLUSION: Candida glabrata endophthalmitis following penetrating keratoplasty can occur in negative donor rim and transport media cultures. The growth of the organism is facilitated by the patient's immunocompromised status. Awareness by the ophthalmologists and appropriate choice of antibiotics are mandatory in this challenging condition. VL - 10 ER - internal-pdf://Muzaliha - Candida glabrata-3483457536/Muzaliha - Candida glabrata.pdf N1 - Muzaliha, Mohd Nor Adil, Hussein Ibrahim, Mohtar Shatriah, Ismail Case Reports England BMC ophthalmology BMC Ophthalmol. 2010 Jun 11;10:18. U2 - 2891680 ID - 1058 ER -