TY - JOUR T1 - Early and fatal immune haemolysis after so-called 'minor' ABO-incompatible peripheral blood stem cell allotransplantation JF - Bone Marrow Transplantation Y1 - 1997 A1 - Oziel-Taieb,S. A1 - Faucher-Barbey,C. A1 - Chabannon,C. A1 - Ladaique,P. A1 - Saux,P. A1 - Gouin,F. A1 - Gastaut,J. A. A1 - Maraninchi,D. A1 - Blaise,D. KW - *Hemolysis KW - ABO Blood-Group System / *immunology KW - Adult KW - Blood Group Incompatibility / *complications KW - Hematopoietic Stem Cell Transplantation / *adverse effects KW - Humans KW - Male KW - Transplantation, Homologous AB - A 38-year-old man, blood group A+, was allotransplanted for multiple myeloma from his fully matched sister, blood group O+. Anti-A antibodies IgG and IgM titres of the donor were low. Allogeneic peripheral blood stem cells were harvested by leukapheresis after subcutaneous administration of G-CSF. Rapid engraftment occurred since 5.6 x 10(9)/l leukocytes were achieved on day +9 post-transplant. At this time a severe immune haemolytic syndrome occurred and direct antiglobulin test was positive (IgG and C3d). Elution showed an anti-A specificity. Evolution was rapidly unfavourable related to multiorgan failure. The patient died on day +20 post-transplant. VL - 19 CP - 11 N1 - Oziel-Taieb, S Faucher-Barbey, C Chabannon, C Ladaique, P Saux, P Gouin, F Gastaut, J A Maraninchi, D Blaise, D ENGLAND Bone Marrow Transplant. 1997 Jun;19(11):1155-6. ID - 1117 ER -