TY - JOUR T1 - A case of an ABO-incompatible renal transplant with abundant intratubular basement membrane immune deposits JF - Clin Transplant Y1 - 2002 A1 - Shiozawa,S. A1 - Ichikawa,T. A1 - Nakazawa,K. A1 - Ehara,T. A1 - Shigematsu,H. KW - ABO Blood-Group System / *immunology KW - Adolescent KW - Basement Membrane / *immunology KW - Complement C3 / analysis KW - Fluorescent Antibody Technique KW - Humans KW - Immunoglobulin G / analysis KW - Kidney / immunology / ultrastructure KW - Kidney Transplantation / *immunology KW - Kidney Tubules / *immunology KW - Male AB - We present a case of a 30-year-old man who received an ABO-incompatible renal transplant from his mother in 1996 after haemodialysis for 3 years. Although his renal function was stable, a renal biopsy was performed while he was in hospital for treatment of herpes zoster in 1999. Light microscopy provided no evidence of obvious acute or chronic rejection but a double contour pattern was observed in many tubular basement membranes (TBM). Immunofluorescence microscopy revealed deposits of IgG and C3 on the TBM in the absence of glomerular deposition. Massive electron-dense deposits were observed clearly by electron microscopy within TBM, revealing splitting and lamellation. This implies that the deposits resulted from the formation of immune complexes, but not from anti-TBM antibody. Although the role of TBM deposits in tubular injury is controversial, careful observation of patients with such deposits may be required because of their potential ability to induce immune reactions. VL - 16 Suppl 8 N1 - Shiozawa, Satoshi Ichikawa, Tohru Nakazawa, Koh Ehara, Takashi Shigematsu, Hidekazu Case Reports Denmark Clinical transplantation Clin Transplant. 2002;16 Suppl 8:68-71. ID - 1401 ER -