TY - JOUR T1 - Donor-derived transmission events in 2013: a report of the Organ Procurement Transplant Network Ad Hoc Disease Transmission Advisory Committee. JF - Transplantation Y1 - 2015 A1 - Green, Michael A1 - Covington, Shandie A1 - Taranto, Sarah A1 - Wolfe, Cameron A1 - Bell, Walter A1 - Biggins, Scott W A1 - Conti, David A1 - DeStefano, G David A1 - Dominguez, Edward A1 - Ennis, Donna A1 - Gross, Thomas A1 - Klassen-Fischer, Mary A1 - Kotton, Camille A1 - LaPointe-Rudow, Dianne A1 - Law, Yuk A1 - Ludrosky, Kristen A1 - Menegus, Marilyn A1 - Morris, Michele I A1 - Nalesnik, Michael A A1 - Pavlakis, Martha A1 - Pruett, Timothy A1 - Sifri, Costi A1 - Kaul, Daniel KW - *Advisory Committees KW - *Disease Transmission, Infectious KW - *Donor Selection KW - *Neoplasms/co [Complications] KW - *Organ Transplantation/ae [Adverse Effects] KW - *Tissue and Organ Procurement KW - *Tissue Donors/sd [Supply & Distribution] KW - Algorithms KW - Decision Support Techniques KW - Humans KW - Neoplasms/ep [Epidemiology] KW - Patient Safety KW - Postoperative Complications/ep [Epidemiology] KW - Risk Assessment KW - Risk Factors KW - Time Factors KW - Treatment Outcome KW - United States/ep [Epidemiology] AB - BACKGROUND: The Organ Procurement Transplant Network Disease Transmission Advisory Committee (DTAC), a multidisciplinary committee, evaluates potential donor-derived transmission events (PDDTE), including infections and malignancies, to assess for donor transmitted events., METHODS: Reports of unexpected PDDTE to Organ Procurement Transplant Network in 2013 were fully reviewed by DTAC. A standardized algorithm was used to assess each PDDTE from a given donor and to classify each individual recipient from that donor., RESULTS: Of 443 total PDDTE submitted, 159 were triaged and not sent out to the full DTAC. Of 284 fully evaluated reports, 32 (11.3%) resulted in a proven/probable (P/P) transmission of infection, malignancy or other conditions to 42 recipients. Of 204 infection events, 24 were classified as P/P affecting 30 recipients, with four deaths. Bacteria were the most frequently reported type of infection, accounting for 99 reports but only 12 recipients from 11 donors experienced P/P transmission. There were 65 donors reported with potential malignancy events and 5 were classified as P/P transmissions with 8 affected recipients and 2 deaths. Additionally, there were 16 noninfection, nonmalignancy reports resulting in 3 P/P transmissions to 4 recipients and 1 death., CONCLUSIONS: There was a 43% increase in the number of PDDTE reported and reviewed in 2013 over 2012. However, the percent with P/P transmission remains low, affecting recipients from 32 donors especially when compared with the more than 14,000 donors recovered annually in the United States. The continued use of the new standard algorithm and triaging process will enhance the reproducibility of DTAC assessments and allow more robust analysis of our aggregate DTAC experience. M1 - wej, 0132144 PB - Green,Michael. 1 Division of Pediatric Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA. 2 United Network for Organ Sharing, Richmond, VA. 3 Division of Transplant Infectious Disease, Duke University Medical Center, Durham, NC. CY - United States VL - 99 SN - 1534-6080 CP - 2 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=medl&NEWS=N&AN=25594557 ID - 4453 ER -