TY - JOUR T1 - Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation. JF - Internal medicine (Tokyo, Japan)// // Intern Med Y1 - 2012 A1 - Arai, Ayako A1 - Imadome, Ken-ichi A1 - Wang, Ludan A1 - Wu, Nan A1 - Kurosu, Tetsuya A1 - Wake, Atsushi A1 - Yamamoto, Hisashi A1 - Ota, Yasunori A1 - Harigai, Masayoshi A1 - Fujiwara, Shigeyoshi A1 - Miura, Osamu KW - *Bone Marrow Transplantation/ae [Adverse Effects] KW - *Epstein-Barr Virus Infections/et [Etiology] KW - *Epstein-Barr Virus Infections/th [Therapy] KW - Adult KW - Base Sequence KW - Chromosomes, Human, X/ge [Genetics] KW - Chromosomes, Human, Y/ge [Genetics] KW - Chronic Disease KW - DNA, Viral/ge [Genetics] KW - Epstein-Barr Virus Infections/ge [Genetics] KW - Epstein-Barr Virus Infections/vi [Virology] KW - Female KW - Herpesvirus 4, Human/ge [Genetics] KW - Herpesvirus 4, Human/ip [Isolation & Purification] KW - Humans KW - In Situ Hybridization, Fluorescence KW - Karyotyping KW - Lupus Erythematosus, Systemic/co [Complications] KW - Lymphoproliferative Disorders/et [Etiology] KW - Lymphoproliferative Disorders/ge [Genetics] KW - Lymphoproliferative Disorders/th [Therapy] KW - Lymphoproliferative Disorders/vi [Virology] KW - Male KW - Recurrence KW - T-Lymphocytes/vi [Virology] KW - Tissue Donors KW - Transplantation, Homologous AB - We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease. M1 - bd6, 9204241 CY - Japan VL - 51 SN - 1349-7235 CP - 7 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=medl&NEWS=N&AN=22466838 ID - 4511 ER -