%0 Journal Article %J Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society %D 2008 %T Human T-cell leukemia virus type I-associated myelopathy following living-donor liver transplantation %A Soyama,A. %A Eguchi,S. %A Takatsuki,M. %A Ichikawa,T. %A Moriuchi,M. %A Moriuchi,H. %A Nakamura,T. %A Tajima,Y. %A Kanematsu,T. %K *Living Donors %K Antiviral Agents / therapeutic use %K Drug Therapy, Combination %K Gait Disorders, Neurologic / etiology %K Graft Rejection / prevention & control %K Hepatitis C / *complications / surgery %K Humans %K Immunosuppressive Agents / therapeutic use %K Interferon Alfa-2b / therapeutic use %K Liver Cirrhosis / *surgery / virology %K Liver Transplantation / *adverse effects %K Male %K Middle Aged %K Paraparesis, Tropical Spastic / complications / drug therapy / *etiology %K Steroids / therapeutic use %K Tacrolimus / therapeutic use %K Treatment Outcome %K Urination Disorders / etiology %X This report describes a patient who developed human T-cell leukemia virus type I-associated myelopathy (HAM) following a living-donor liver transplantation (LDLT) for liver cirrhosis due to hepatitis C virus (HCV) infection. Both the recipient and the living donor (his sister) were human T-cell leukemia virus type I (HTLV-I) carriers. Since the LDLT, he had been treated with immunosuppressive drugs such as tacrolimus and steroids as well as interferon-alpha to prevent rejection and a recurrence of the HCV infection, respectively. Even though the HTLV-I proviral load had decreased upon interferon treatment, he developed a slowly progressive gait disturbance with urinary disturbance 2 years after the LDLT and was diagnosed with HAM. This appears to be the first report of HAM development in an HLTV-I-infected LDLT recipient. %B Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society %7 39563 %V 14 %P 647 - 50 %8 May %G eng %N 5 %9 Case Reports %M 18433046 %R 10.1002/lt.21414