%0 Journal Article %J Eur J Endocrinol %D 1995 %T Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant %A Thomson,J. A. %A Wilson,R. M. %A Franklin,I. M. %K Adult %K Autoantibodies / metabolism %K Autoimmune Diseases / *etiology / *genetics / immunology %K Bone Marrow Transplantation / *adverse effects / immunology %K Family Health %K Female %K Humans %K Karyotyping %K Leukemia, Myeloid, Acute / genetics / therapy %K Lymphocytes / metabolism %K Male %K Radioimmunoassay %K Thyroiditis, Autoimmune / genetics / immunology %K Thyrotoxicosis / *etiology / *genetics / immunology %K Transplantation, Homologous %X This case report is on a 25-year-old male with acute myeloblastic leukaemia who achieved a remission after cytoxic therapy and whole-body irradiation. He received a bone marrow transplant from his human leucocyte antigen (HLA)-identical sister who had unsuspected autoimmune thyroid disease. Nine months later the bone marrow recipient developed thyrotoxicosis of autoimmune type at a time when his circulating lymphocytes were of 46XX karyotype. It is suspected that the thyrotoxicosis resulted from the transplantation of a clone of lymphocytes predisposed to the production of thyroid-stimulating autoantibodies. %B Eur J Endocrinol %7 35004 %V 133 %P 564 - 6 %8 Nov %G eng %N 5 %M 7581986