%0 Journal Article %J Annals of hematology//Ann Hematol %D 2004 %T Delayed hemolytic transfusion reaction due to anti-S antibody in patient with anti-Jk(a) autoantibody and multiple alloantibodies. %A Guastafierro, S %A Sessa, F %A Cuomo, C %A Tirelli, A %K *Autoantibodies/im [Immunology] %K *Blood Transfusion/ae [Adverse Effects] %K *Hemolysis/im [Immunology] %K *Isoantibodies/im [Immunology] %K *Kidd Blood-Group System/im [Immunology] %K *MNSs Blood-Group System/im [Immunology] %K Autoantibodies/bl [Blood] %K Female %K Humans %K Isoantibodies/bl [Blood] %K Middle Aged %K Time Factors %X We describe the case of a 60-year-old woman with a delayed hemolytic transfusion reaction (DHTR). She had a history of an ulcerative colitis, blood transfusion because of rectal bleeding, and surgical removal of descendent and sigmoid colon. At admission, laboratory data showed Hb 6.3 g/dL, reticulocytes 120 x 10(9)/L, serum total bilirubin 1.2 mg/dL (direct bilirubin: 0.2 mg/dL). Pretransfusion antibody screening procedures were positive. A monospecific autoanti-Jk(a) and three alloantibodies (anti-c, -E, -K) were identified by immunohematologic studies. The patient received two units of crossmatch compatible concentrated red blood cells. Six days later biochemical serum values showed Hb 6.2 g/dL, LDH 975 I.U./L and total bilirubin 2.95 mg/dL (direct 0.35 mg/dL). Crossmatches with red cell suspension of transfused blood units and a post-transfusion serum were repeatedly positive. Laboratory tests showed the presence of anti-S alloantobody in the serum and eluate. Moreover, pre-transfusion serum of the patient was retrospectively retested: anti-S was not detected. These data suggested a DHTR. The present case is unusual and interesting because of the association of a rare autoanti-Jk(a), non responsible for anemia, and four alloantibodies of which anti-S involved in a DHTR. %B Annals of hematology//Ann Hematol %I Guastafierro,S. Department of Hematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy. %C Germany %V 83 %P 307 - 8 %8 2004 %@ 0939-5555 %G eng %N 5 %< http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med5&NEWS=N&AN=15064858