%0 Journal Article %J Transplant infectious disease : an official journal of the Transplantation Society// Transpl Infect Dis %D 2012 %T Donor-derived organ transplant transmission of coccidioidomycosis. %A Dierberg, K L %A Marr, K A %A Subramanian, A %A Nace, H %A Desai, N %A Locke, J E %A Zhang, S %A Diaz, J %A Chamberlain, C %A Neofytos, D %K *Antifungal Agents/tu [Therapeutic Use] %K *Coccidioides/ip [Isolation & Purification] %K *Coccidioidomycosis/tm [Transmission] %K *Fungemia/mi [Microbiology] %K *Organ Transplantation/ae [Adverse Effects] %K *Tissue Donors %K Adolescent %K Coccidioidomycosis/di [Diagnosis] %K Coccidioidomycosis/dt [Drug Therapy] %K Fatal Outcome %K Female %K Fluconazole/tu [Therapeutic Use] %K Fungemia/di [Diagnosis] %K Fungemia/dt [Drug Therapy] %K Humans %K Immunosuppression/mt [Methods] %K Male %K Middle Aged %K T-Lymphocytes/im [Immunology] %K Tissue and Organ Harvesting %K Travel %K Young Adult %X Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.Copyright © 2011 John Wiley & Sons A/S. %B Transplant infectious disease : an official journal of the Transplantation Society// Transpl Infect Dis %C Denmark %V 14 %P 300 - 4 %8 2012// %@ 1399-3062 %G eng %N 3 %< http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=medl&NEWS=N&AN=22176496