| Title | Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion. |
| Publication Type | Journal Article |
| Year of Publication | 1994 |
| Authors | Dhodapkar M, Goldberg SL, Tefferi A, Gertz MA |
| Journal | Am J Hematol |
| Volume | 45 |
| Issue | 2 |
| Pagination | 187 - 8 |
| Date Published | Feb |
| ISSN | 0361-8609 |
| Accession Number | 7908165 |
| Keywords | Brain Diseases, Cell Transplantation, Cryopreservation, Dimethyl Sulfoxide, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Plasmapheresis |
| Abstract | We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a significant toxic reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. |
| Notify Library Reference ID | 439 |
