Record to update:
Adverse Occurrence type:
MPHO Type:
Time to detection:
12 months
Alerting signals, symptoms, evidence of occurrence :
Liver ultrasound of the anastomoses showed a 1.5 cm mass. Biopsy showed a moderately differentiated mucin producing adenocarcinoma.
Demonstration of imputability or root cause:
Tumor, donor, and recipient DNA was isolated from the paraffin embedded liver biopsy, pretransplant liver donor biopsy and explanted liver tissue, respectively. Microsatellite analysis was performed by polymerase chain reaction (PCR) using 5 markers: D5S346, ACTC, D2S123, D18S34, and TP53. The allelic patterns of tumor DNA were identical to those of donor DNA and were distinct from the DNA profile of the recipient.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
case report
Suggest new keywords:
deceased donor
carcinoma of unknown primary site
liver transplant
transplantectomy
DNA typing
malignancy
case report
Adverse occurrence description:
Case report: Adenocarcinoma of unknown primary site
Expert comments for publication:
Paper is focused on use of microsatellite analysis to determine donor versus recipient tumor origin. The patient underwent radiofrequency tumor ablation and later allograft hepatectomy and retransplantation. Patient was without tumor 8 months following retransplant. Retrospective donor serum analysis showed elevated CA19-9 level.