Adverse Occurrence type:
Up to 70% of liver transplant (LT) recipients
Time to detection:
12 - 36 months
Alerting signals, symptoms, evidence of occurrence:
92 consecutive LT recipients for whom prospectively stored frozen sera were available for autoantibodies assessment by immunofluorescence were evaluated. Antinuclear (ANA), antismooth muscle (ASMA), and anti liver–kidney microsomal type 1 (anti-LKM) in up to 70% of the liver transplant recipients.
Demonstration of imputability or root cause:
Patients had previously tested negative became autoantibody positive after grafting. Patients with graft dysfunction had a significantly higher autoantibody prevalence irrespective of the etiology of liver injury as compared to those patients with persistently normal liver biochemistry.
Foschi, A., Zavaglia, C.A., Fanti, D., Mazzarelli, C., Perricone, G., Vangeli, M., Vigano, R. and Belli. L.S. (2015). Autoimmunity after liver transplantation: a frequent event but a rare clinical problem. Clin Transplant DOI 10.1111/ctr.12498.