Status:
Ready to upload
Record number:
1167
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Post–lung transplant Rhesus PLS (passenger lymphocyte syndrome), occurring once in every 31 cases
Alerting signals, symptoms, evidence of occurrence:
Severe hemolysis in one recipient and two cases with serologic evidence alone (positive DAT).
Demonstration of imputability or root cause:
Three of 97 alloimmunized donors were identified by the signal of apparent red blood cells autoimmunization with self or mimicking-specificities after lung transplantation.
Imputability grade:
2 Probable
Groups audience:
Keywords:
References:
Suggest new keywords:
Rh immunization
passenger lymphocyte syndrome
lung
Suggest references:
Cserti-Gazdewich, CM, et al, 2009. Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature.Transfus Med Rev 23:134-45. Shortt, J., Westall, G.P., Roxby,, D.,Chen, J. W., Snell, G.I., Polizzotto, M.N., Magrin, G., Webb, A., Street, A.M., Borosak, M., Wood, E.M. and Cole-Sinclair, M.F. (2008). A 'dangerous' group O donor: severe hemolysis in all recipients of organs from a donor with multiple red cell alloantibodies. Am J Transplant 8(3): 711-14.
Shortt, J., Westall, G.P., Roxby,, D.,Chen, J. W., Snell, G.I., Polizzotto, M.N., Magrin, G., Webb, A., Street, A.M., Borosak, M., Wood, E.M. and Cole-Sinclair, M.F. (2008). A 'dangerous' group O donor: severe hemolysis in all recipients of organs from a donor with multiple red cell alloantibodies. Am J Transplant 8(3): 711-14.