Status:
Ready to upload
Record number:
1251
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case Report
Time to detection:
During transfusion
Alerting signals, symptoms, evidence of occurrence:
Acute febrile and systemic reaction to the transfusion.
Demonstration of imputability or root cause:
Crossmatch using post-transfusion sample was negative at immediate spin but 3+ incompatible at AHG phase. Post-transfusion sample positive for IgG DAT and demonstrated agglutination with Kpa positive cells. Patient types as Kpa negative and donor cells were Kpa positive.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Reference attachment:
Suggest references:
Padmore, R., Berardi, P., Erickson, K., Desjardins, D., Giulivi, A., Tokessy, M., Neurath, D. and Saidenberg, E. (2014). Acute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch. Transfus Apher Sci 51(2):168-171.
Expert comments for publication:
A case of antibody to low frequency antigen like Kpa that maybe missed on routine antibody screen. Such missed antibodies can cause hemolytic reactions as in this case.