Acute Hemolytic Transfusion Reaction (AHTR), anti-Wr

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case Report
Time to detection: 
85 minutes
Alerting signals, symptoms, evidence of occurrence: 
Following the transfusion, patient had bilirubin and urobilinogen in his urine and a fall in haemoglobin of nearly 2 g dL (-1).
Demonstration of imputability or root cause: 
Clinical and serology results.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
anti-Wr, Diego
Reference attachment: 
Suggest references: 
Cherian. G., Search, S., Thomas, E., Poole, J., Davies, S.V. and Massey, E. (2007). An acute haemolytic transfusion reaction caused by anti-Wr. Transfus Med 17(4):312-314.
Expert comments for publication: 
Anti-Wra of the Diego system, a relatively common antibody to an antigen of very low frequency, has caused severe hemolytic transfusion reactions. It has also been implicated in delayed hemolytic transfusion reactions.