Autoimmune thrombocytopenia

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Very common. Poly factorial, GvHD and viral with 11 of 26 viral related to CMV.
Time to detection: 
60 - 649 days
Alerting signals, symptoms, evidence of occurrence: 
Prolonged thrombocytopenia characterized as up to 60 days post transplant; Late thrombocytopenia characterized as initial recovery and then thrombocytopenia after 60 days post transplant.
Demonstration of imputability or root cause: 
Positive for platelet associated IgG
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
autoimmune, thrombocyopenia, bone marrow, rrow biopsy, CBPAb (cell bound antiplatelet antibody), CMV (cytomegalovirus), GVHD (graft versus host disease), IgG (immunoglobulin G)
Reference attachment: 
Suggest references: 
- Cahn, JY, et al, 1989. Autoimmune-like thrombocytopenia after bone marrow transplantation. Blood 74:2771. - Anasetti C1, Rybka W, Sullivan KM, Banaji M, Slichter SJ., Graft-v-host disease is associated with autoimmune-like thrombocytopenia. Blood. 1989 Mar;73(4):1054-8.
To index also the second reference provided (Evi)
Expert comments for publication: 
Post transplant development or (donor derived) thyroid disease is well described.