Trypanosoma cruzi

FIRST CASE: living donor known positive by ELISA and negative by PCR, treated with 5-nitrofurazone prior to donation. Recipient case 1 received prophylactic treatment to avoid infection and never seroconverted after 6 years of follow-up. Recipient case 2: living donor known positive by ELISA and PCR. 5-nitrofurazone was provided to recipient prohpylacticaly for one month prior to transplant through to 2 months after transplant. PCR negative at 7 months post-transplant. SECOND CASE: organ donor with positive serology for Trypanosoma cruzi, whose kidneys were implanted into two different recipients. Prophylaxis was administered with benznidazole for 3 weeks. Over the course of two years of serological and clinical follow-up, no evidence of Chagas' transmission or infection was observed.