Status:
Ready to upload
Record number:
1576
Adverse Occurrence type:
MPHO Type:
Time to detection:
8 days
Alerting signals, symptoms, evidence of occurrence:
Eight days after receiving two units of packed red cells, the patient's urine was strongly positive for hemoglobin; serum-free hemoglobin was 125 mg/dl. Serum contained a clearly reactive Rh antibody of the ant-f alloantibody appearing as an anamnestic response to transfusion of seemingly compatible but f-positive blood.
Demonstration of imputability or root cause:
Serum contained a clearly reactive Rh antibody of anti-f specificity and a weakly reactive anti-Kell. The DHTR was probably casused by the anti-f alloantibody appearing as an anamnestic response to transfusion of seemingly compatilble but f-positive blood.
Imputability grade:
2 Probable
Groups audience:
Keywords:
References:
Suggest new keywords:
DHTR, anamnestic, serum free hemoglobin, urine hemoglobin, anti-f
Reference attachment:
Suggest references:
O'Reilly, R.A., Lombard, C.M. and Azzi, R.L. (1985). Delayed hemolytic transfusion reaction associated with Rh antibody anti-f: first reported case. Vox Sang 49(5):336-339.
Note:
OK ONCE THE REFERENCE IS INDEXED (EVI)
Expert comments for publication:
Rh (D) antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. Anti-ce (anti-f) is often seen in combination with anti-c.