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Adverse Occurrence type:
Time to detection:
within 24 hours
Alerting signals, symptoms, evidence of occurrence:
Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain,nausea/vomiting,diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR.
Demonstration of imputability or root cause:
Clinical or laboratory features of hemolysis are present along with serological evidence for red cell antibodies including elution of antibodies from the patient's red cells. Anti-Duffy antibodies include: Fy(a), Fy(b), Fy(3), Fy5
Suggest new keywords:
Fy(a), Fy(b), Fy(3), Fy5,
Poole, J. and Daniels, G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1):58-71.
Expert comments for publication:
In the Duffy system, Anti-Fya, -Fyb, and -Fy3 have caused severe immediate and delayed hemolytic transfusion reactions, and anti-Fy5 has been incriminated in delayed reactions. The most commonly encountered immune antibodies are D > K> E> Fya> Jka.