Delayed Hemolytic Transfusion Reaction (DHTR) with hyperhemolysis in a child with Beta-thalassemia

Status:

Ready to upload

Record number:

1622

Adverse Occurrence type:

Delayed Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Single case report

Time to detection:

3 weeks

Alerting signals, symptoms, evidence of occurrence:

Three weeks after first transfusion the patient developed anemia and hyperhemolysis.

Demonstration of imputability or root cause:

Complement positive (C3d) but IgG negative serologic evaluation

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

RBC (red blood cell)

DAT (direct antiglobulin test)

DHTR (delayed hemolytic transfusion reaction)

beta thalassemia

References:

Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta-thalassemia: challenges in treatment.

Suggest new keywords:

DHTR (delayed hemolytic transfusion reaction)

C3d

beta thalassemia

Reference attachment:

DHTR Hyperhemolysis, Hannema, 2010.pdf

Suggest references:

Hannema SE, Brand A, van Meurs A, Smiers FJ. (2010). Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta-thalassemia: challenges in treatment. Transfusion 50:429-32

Note:

Ready to upload once the taxonomy is sorted: Harm to a recipient/Immunological complications/Delayed Hemolytic Reaction (Evi)

Expert comments for publication:

Exceptionally severe case that persisted through two bone marrow transplants and refractory to standard autoimmune therapies.