Adverse Occurrence type:
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022): Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Not specified. Agressive metastatic disease described in outcome. The patient died within 30 days after transplantation due to an irreversible rejection and had extensive replacement of his heart allograft by tumor.
Demonstration of imputability or root cause:
Assessment of disease transmission studied by biopsy confirmatory with comparison of the recipient cancer to the primary donor tumour or in some cases genetic allelic analysis. In this particular case, the same histological type of tumour was known to be present in the donor (identified as having an occult choriocarcinoma after donation and implantation), with no further specification provided.
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Expert comments for publication:
This is one case in a series of tumor transmissions to cardiothoracic recpients reported by the Penn Registry.