Record number:
258
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
5 of 8 recipients
- Most recent risk assessment for non-melanoma skin cancer (Council of Europe, 2025):
Non-melanoma skin cancer diagnosed during donor procurement or in the donor history:
Basal cell and squamous cell carcinoma of the skin are considered minimal risk due to very rare metastases. Kaposi sarcoma, Merkel cell carcinoma and skin sarcoma are considered an unacceptable risk.
Time to detection:
9 - 40 months
Alerting signals, symptoms, evidence of occurrence:
Appearance of bluish-red or purple bumps on skin lesionsr on the feet or ankles, thighs, arms, hands, face.
Demonstration of imputability or root cause:
Used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest references:
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Expert comments for publication:
KS in transplant patients arises from either reactivation of HHV8 or infection transmission by the donor. The purpose of this study was to show that the cells of the KS lesions are at least in part derived from donor cells. This does not imply transplant transmission of KS in this series.