Adverse Occurrence type:
Most recent risk assessment for melanoma (Council of Europe, 2018): donors with active melanoma represent an unacceptable risk for organ donation. Donors with a history of treated melanoma are generally considered to represent a high transmission risk. Opinions vary. The SaBTO/UK states that a superficial spreading melanoma with tumor thickness less than 1.5 mm and with curative surgery and cancer free interval of more than five years is associated with a low transmission risk, although this conclusion is based on a small number of cases. UNOS/DTAC considers all patients with a history of melanoma to represent a high risk for transmission.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Liver recipient assessed after notification of transmission in the two kidney recipients
Demonstration of imputability or root cause:
Donor with not known condition - Two kidney recipients and liver recipient affected. No envidence of transmission in the heart recipient. - Kidney recipient 1: Gene studies determined the origin of the tumor to be donor in type (tumour cells expressed HLA class 1 antigens mismatched in the recipient and mRNA for the costimulator B7, and the cytokines GM-CSF, IL-1 alpha and beta)
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