Case report: Melanoma after liver transplant (1998)

Record number: 
294
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Most recent risk assessment for melanoma (Council of Europe, 2022): Due to the very aggressive behaviour of this tumour, it is considered an unacceptable risk for organ donation. Malignant melanoma in the donor history: Due to the lack of exhaustive data, transplanting organs from donors with treated malignant melanoma must still be considered to be associated with a high transmission risk. If precise donor data about staging, therapy, follow-up and recurrence-free survival are available, and evaluation by the dermato-oncologist concludes there is a low probability of recurrence and metastasis, organ donation might be considered for selected recipients.
Time to detection: 
9 months
Alerting signals, symptoms, evidence of occurrence: 
Liver recipient assessed after notification of transmission in the two kidney recipients
Demonstration of imputability or root cause: 
Donor with not known condition - Two kidney recipients and liver recipient affected. No envidence of transmission in the heart recipient. - Kidney recipient 1: Gene studies determined the origin of the tumor to be donor in type (tumour cells expressed HLA class 1 antigens mismatched in the recipient and mRNA for the costimulator B7, and the cytokines GM-CSF, IL-1 alpha and beta)
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Case report
Kidney transplant
Liver transplant
Heart transplant
Suggest references: 
AAA