Case report: Myelodysplastic syndrome/acute myeloid leukemia

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
3.5 years
Alerting signals, symptoms, evidence of occurrence: 
2% blasts noted in PB following respiratory infection/fever.  F/U BM biopsy was hypercellular (80-85%) with 18% glasts; megakaryocytic dysplasia.
Demonstration of imputability or root cause: 
Minisatillite polymorphism tested on CD34(+) cells. 100% donor origin in engraftment studies.
Imputability grade: 
0 Excluded
Groups audience: 
Suggest new keywords: 
Living donor
Hematopoietic stem cell transplant
Suggest references: 
Expert comments for publication: 
Donor had no evidence of disease at the time the recipient presented with MDS and no prior exposure to chemotherapy. Most likely to represent therapy-relatred MDS in the recipient, although could represent de novo disease (less likely).