Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
2% blasts noted in PB following respiratory infection/fever. F/U BM biopsy was hypercellular (80-85%) with 18% glasts; megakaryocytic dysplasia.
Demonstration of imputability or root cause:
Minisatillite polymorphism tested on CD34(+) cells. 100% donor origin in engraftment studies.
Suggest new keywords:
Hematopoietic stem cell transplant
Expert comments for publication:
Donor had no evidence of disease at the time the recipient presented with MDS and no prior exposure to chemotherapy. Most likely to represent therapy-relatred MDS in the recipient, although could represent de novo disease (less likely).