Adverse Occurrence type:
Alerting signals, symptoms, evidence of occurrence:
Demonstration of imputability or root cause:
Unlikely but possible. The incidence of Hodgkin disease in the cohort of donors investigated in Hölig et. al. turned out to be significantly different from the natural incidence in the German population. Regarding the incidence of Hodgkin disease after PBSC mobilization, there are only anecdotal reports in the literature. A prolonged and thorough follow-up study is needed to understand the incidence of Hodgkin's disease in living donors.
 Halter, J.; Kodera, Y.; Ispizua, A.U.; Greinix, H.T.; Schmitz, N.; Favre, G.; Baldomero, H.; Niederwieser, D.; Apperley, J.F.; Gratwohl, A. Severe events in donors after allogeneic hematopoietic stem cell donation Haematologica 2009; 94 (1) :94 - 101  WMDA, World Marrow Donor Association. SEAR Registry, 12th ed. 2010;  Hölig, K.; Kramer, M.; Kroschinsky, F.; Bornhäuser, M.; Mengling, T.; Schmidt, A.H.; Rutt, C.; Ehninger, G. Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors. Blood 2009; 114 (18) :3757 - 63