Plasmodium falciparum

Record number:

670

Adverse Occurrence type:

Plasmodium

MPHO Type:

Kidney

Time to detection:

10 - 30 days

Alerting signals, symptoms, evidence of occurrence:

Fever, intravascular hemolysis, thrombocytopenia, blood smear, transaminitis, renal failure, neurological symptoms, coma, multi-organ failure; asymptomatic parasitemia

Demonstration of imputability or root cause:

In all cases, donor had been to or resided in a malaria endemic region (sometimes long before donation), was asymptomatic and was tested retrospectively. Recipients from common donors became infected and those who were diagnosed very early and treated pre-emptively did well, in contrast to symptomatic patients. (Ref 113) West African, asymptomatic donor found retrospectively to be seropositive, with Plasmodium falciparum found in blood > 1 year after having left Cameroon. Recipient of heart diagnosed day 18, trophozoites in thin smear, died of malaria. Recipient of one of the kidneys had Plasmodium falciparum detected in blood but died of disseminated CMV infection.

Imputability grade:

3 Definite/Certain/Proven

Keywords:

malaria

fever

trophozoites

subclinical parasitemia

MOF (multiple organ failure)