Case report: Glioblastoma multiforme (1993)

Record number:

Adverse Occurrence type:

Astrocytoma/glioblastoma multiforme (WHO grade 4)

MPHO Type:

Estimated frequency:

- Most recent risk assessment for astrocytoma WHO grades 3 or 4 and glioblastoma WHO grade 4 (Council of Europe, 2025): Spontaneous extraneural metastases of grade 3 astrocytomas and grade 4 glioblastomas are rare, but such metastases have been observed, and seem to occur more frequently when associated with prior surgical treatment and/or ventriculo-peritoneal drainage or chemo-/radiotherapy. Potential donors with WHO grade 3 astrocytomas can be accepted as organ donors. Transmission risk is considered low to intermediate for tumours without any risk factors. Potential donors with glioblastoma IDH-wildtype or astrocytoma IDH-mutant are considered intermediate risk for transmission, depending on different national recommendations, which are expected to be adjusted with increasing evidence. The transmission risk is increased in all cases with previous interventions such as tumour resection, ventriculo-peritoneal/-atrial drainage and/or cranial chemo-/radiotherapy.

Time to detection:

17 -18 months

Alerting signals, symptoms, evidence of occurrence:

Mass in both recipients of the kidneys from the same donor. One patient presented with fever and mass detected in graft. Second patient developed hypertension around the same time and was evaluated for mass following information from the physicians treating the first recipient.

Demonstration of imputability or root cause:

Condition known in the donor who had been treated with surgery and radiotherapy. Two recipients affected from the same donor. Kidney graft removal was performed in both recipients. Both were alive and disease-free 15 months after transplantectomy. Histology and immunocytochemistry confirmed diagnosis in both patients.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Malignancy

Keywords:

GBM (glioblastoma multiforme)