Splenic rupture

Record number:

883

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Rare

Alerting signals, symptoms, evidence of occurrence:

Abdominal pain, hypotension, shock on days of injections

Demonstration of imputability or root cause:

Definite/probable. Temporal relationship to GCSF.

Keywords:

G-CSF (granulocyte colony-stimulating factor)

PBSC (peripheral blood stem cells)

References:

World Marrow Donor Association. SEAR Registry, 12th ed.

Splenic rupture after granulocyte-colony-stimulating factor mobilization in a peripheral blood progenitor cell donor

Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells

Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization

Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature

Spontaneous rupture of spleen during peripheral blood stem-cell mobilisation in a healthy donor

Stem cell mobilisation with 16 microg/kg vs 10 microg/kg of G-CSF for allogeneic transplantation in healthy donors

Critical overview of the current status of organ donors with primary central nervous system tumors

Suggest references:

aaa