Human T-lymphotropic virus type I (HTLV-I)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
6 years
Alerting signals, symptoms, evidence of occurrence: 
Donor derived adult T-cell leukaemia in a 55 year old woman after a non myeloablative peripheral blood stem cell transplant. The stem cells had been harvested from her brother, an asymptomatic carrier of human T-cell lymphotropic virus type 1 (HTLV-1).
Demonstration of imputability or root cause: 
XY-FISH showed an XY genotype of the tumour cells, suggesting that they had originated from the donated leucocytes.
Imputability grade: 
3 Definite/Certain/Proven
Suggest references: 
Nakamizo, A.; Akagi, Y.; Amano, T.; Suzuki, S.O.; Otsuka, R.; Abe, Y.; Yoshimoto, K.; Iwaki, T.; Sasaki, T. Donor-derived adult T-cell leukaemia Lancet 2011; 377 (9771) :1124