Transplantation in patients with primary renal malignancies

TitleTransplantation in patients with primary renal malignancies
Publication TypeJournal Article
Year of Publication1977
AuthorsPenn I
Pagination424 - 34
Date PublishedDec
Accession Number339439
Keywords*Kidney Transplantation, Adenocarcinoma / therapy, Adolescent, Adult, Antineoplastic Agents / adverse effects, Child, Child, Preschool, Female, Graft Rejection / drug effects, Humans, Immunosuppressive Agents / adverse effects, Infant, Kidney Neoplasms / *therapy, Male, Middle Aged, Neoplasm Metastasis, Prognosis, Recurrence, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Time Factors, Transplantation, Homologous

Seventy-three patients with primary renal neoplasms underwent kidney transplantation. Three distinct groups were identified. Thirty-four patients (group 1), who underwent antineoplastic therapy 1 year or less before transplantation, developed metastases or recurrences in 53% of the cases. In contrast, none of 15 patients in group 2 had this problem. All of these patients had a waiting period of at least 15 months between nephrectomy and transplantation. These findings emphasize the value of a lengthy waiting period between treatment of the neoplasm and performance of transplantation with its associated immunosuppressive therapy. Group 3 also had a favorable outcome. All had incidentally discovered renal malignancies, in 18 patients during the work-up of chronic renal failure or after bilateral nephrectomy in preparation for renal transplantation, and in 6 several months after transplantation when the recipient's own kidneys were removed or autopsy examination was performed. None of these 24 patients developed recurrences or metastases.

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