| Title | Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Bauwens D, Hantson P, Laterre PF, Michaux L, Latinne D, De Tourtchaninoff M, Cosnard G, Hernalsteen D |
| Journal | Leukemia & lymphoma |
| Volume | 46 |
| Issue | 11 |
| Pagination | 1671 - 4 |
| Date Published | Nov |
| Type of Article | Case Reports |
| ISSN | 1042-8194 (Print) 1026-8022 (Linking) |
| Accession Number | 16236621 |
| Keywords | Cryopreservation / methods, Dimethyl Sulfoxide / *adverse effects, Fatal Outcome, Humans, Lymphoma, Large B-Cell, Diffuse / complications / therapy, Male, Neurotoxicity Syndromes / *etiology, Peripheral Blood Stem Cell Transplantation / *adverse effects, Recurrence, Seizures / *chemically induced, Tissue Preservation / methods |
| Abstract | We report the case of a patient who received two infusions of dimethylsulfoxide (DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings (electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities (magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO. |
| DOI | 10.1080/10428190500235611 |
| Alternate Journal | Leuk Lymphoma |
| Notify Library Reference ID | 146 |
