| Title | Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Trofe J, Buell JF, Beebe TM, Hanaway MJ, First MR, Alloway RR, Gross TG, Succop P, Woodle ES |
| Journal | Am J Transplant |
| Volume | 5 |
| Issue | 4 Pt 1 |
| Pagination | 775 - 80 |
| Date Published | Apr |
| Accession Number | 15760401 |
| Keywords | *Kidney Transplantation, *Registries, *Survival, Graft Rejection / prevention & control, Immunosuppression, Lymphoproliferative Disorders / *mortality / physiopathology / therapy, Survival Analysis |
| Abstract | Significant mortality is associated with post-transplant lymphoproliferative disorder (PTLD) in kidney transplant recipients (KTX). Univariate/multivariate risk factor survival analysis of US PTLD KTX reported to Israel Penn International Transplant Tumor Registry from November 1968 to January 2000 was performed. PTLD presented 18 (median) (range 1-310) months in 402 KTX. Death rates were greater for those diagnosed within 6 months (64%) versus beyond 6 months (54%, p = 0.04). No differences in death risk for gender, race, immunosuppression, EBV, B or T cell positivity were identified. Death risk increased for multiple versus single sites (73% vs. 53%, hazards ratio (HR) 1.4). A 1-year increase in age increased HR for death by 2%. Surgery was associated with increased survival (55% vs. 0% without surgery) (p |
| Notify Library Reference ID | 1556 |
