| Title | Trypanosoma cruzi trans-sialidase inhibits human lymphocyte proliferation by nonapoptotic mechanisms: implications in pathogenesis and transplant immunology |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Vercelli CA, Hidalgo AM, Hyon SH, Argibay PF |
| Journal | Transplant Proc |
| Volume | 37 |
| Issue | 10 |
| Pagination | 4594 - 7 |
| Date Published | Dec |
| ISSN | 0041-1345 (Print) 0041-1345 (Linking) |
| Accession Number | 16387178 |
| Keywords | *Transplantation Immunology, Animals, Antigens, CD / analysis, Apoptosis / drug effects, Cell Division / drug effects, Cell Transplantation / *methods, Glycoproteins / *pharmacology, Humans, Lymphocyte Culture Test, Mixed, Lymphocytes / *cytology / drug effects, Mice, Neuraminidase / *pharmacology, Trypanosoma cruzi / *enzymology |
| Abstract | Chiefly an intracellular parasite, Trypanosoma cruzi has a transient blood-borne stage (trypomastigote), the acute phase of Chagas' disease, during which surface trans-sialidase is expressed and shed by the parasite. It's immunosuppressive through the induction of apoptosis. Herein, we investigated the role of trans-sialidase as an immune modulator of allo- and xenoreactions. Trans-sialidase strongly inhibited human lymphocyte proliferation; a role for the interleukin-2 receptor CD25 was suggested by flow cytometry. These results may have implications both for the pathogenesis of Chagas' disease and for transplantation immunology. |
| DOI | 10.1016/j.transproceed.2005.10.013 |
| Short Title | Trypanosoma cruzi trans-sialidase inhibits human lymphocyte proliferation by nonapoptotic mechanisms: implications in pathogenesis and transplant immunology |
| Notify Library Reference ID | 1591 |
