ABO mismatch increases transplant-related morbidity and mortality in patients given nonmyeloablative allogeneic HPC transplantation

TitleABO mismatch increases transplant-related morbidity and mortality in patients given nonmyeloablative allogeneic HPC transplantation
Publication TypeJournal Article
Year of Publication2003
AuthorsWorel N, Kalhs P, Keil F, Prinz E, Moser K, Schulenburg A, Mitterbauer M, Mannhalter C, Mayr WR, Schwarzinger I, Hocker P, Lechner K, Greinix HT
JournalTransfusion
Volume43
Issue8
Pagination1153 - 61
Date PublishedAug
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number12869124
Keywords*ABO Blood-Group System, Adult, Aged, Blood Group Incompatibility / *complications, Central Nervous System Diseases / etiology, Disease Progression, Female, Graft vs Host Disease / etiology, Hematologic Diseases / etiology, Hematopoietic Stem Cell Transplantation / *adverse effects / *mortality, Hospitalization, Humans, Immune System Diseases / etiology, Infection / etiology, Male, Middle Aged, Recurrence, Survival Analysis, Transplantation, Homologous
Abstract

BACKGROUND: ABO mismatch has not been thought to affect the outcome of patients undergoing myeloablative conditioning and allogeneic HPC transplantation. Data on transplant-related complications after ABO-mismatched transplantation after nonmyeloablative conditioning are limited. STUDY DESIGN AND METHODS: Therefore, 40 patients were analyzed after nonmyeloablative conditioning with regard to ABO compatibility. Eleven received a minor and bidirectional and 8 a major ABO-mismatched graft. RESULTS: Four patients had evidence of hemolysis during engraftment, being lethal in one, and three developed pure RBC aplasia. Six patients in the ABO-mismatched group developed thrombotic microangiopathy, and three of them died. ABO-identical and ABO-mismatched patients had a similar incidence of GVHD. Viral infections occurred in both groups in equal shares. Patients with an ABO-mismatch had to be rehospitalized until Day 100 for a median of 19 days versus 0 days in the identical group (p

DOI
Notify Library Reference ID1656

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