Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation

TitleTransient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation
Publication TypeJournal Article
Year of Publication2006
AuthorsYoshida I, Matsuo K, Teshima T, Hashimoto D, Tanimoto Y, Harada M, Tanimoto M
JournalTransfusion
Volume46
Issue2
Pagination186 - 92
Date PublishedFeb
Type of ArticleClinical Trial
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number16441593
Keywords*Peripheral Blood Stem Cell Transplantation, Adolescent, Adult, Blood Gas Analysis, Carbon Dioxide / blood, effects, Female, Granulocyte Colony-Stimulating Factor / administration & dosage / *adverse, Hematopoietic Stem Cell Mobilization / *adverse effects / *methods, Humans, Leukocyte Count, Male, Middle Aged, Oxygen / blood, Prospective Studies, Pulmonary Gas Exchange / drug effects, Respiratory Insufficiency / *chemically induced / physiopathology, Transplantation, Homologous
Abstract

BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 microg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 x 10(9), 33.4 x 10(9), and 33.6 x 10(9) per L, respectively. The mean PaO(2) values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p

DOI10.1111/j.1537-2995.2006.00700.x
Alternate JournalTransfusion
Notify Library Reference ID1670

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