Adoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves' disease

TitleAdoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves' disease
Publication TypeJournal Article
Year of Publication1999
AuthorsBerisso GA, van Lint MT, Bacigalupo A, Marmont AM
JournalBone Marrow Transplant
Volume23
Issue10
Pagination1091 - 2
Date PublishedMay
ISSN0268-3369 (Print) 0268-3369 (Linking)
Accession Number10373079
KeywordsAdoptive Transfer, Adult, Autoantibodies / blood, Autoimmune Diseases / *etiology / immunology, Female, Graves Disease / *immunology, Hematopoietic Stem Cell Transplantation / *adverse effects, HLA Antigens, Humans, Hyperthyroidism / *etiology / immunology, Leukemia, Myeloid, Acute / therapy, Receptors, Thyrotropin / immunology, Tissue Donors, Transplantation, Homologous
Abstract

Autoimmune diseases which follow allogeneic BMT from a donor who is a patient or a carrier of an autoimmune condition are considered to be a paradigm of adoptive autoimmunity. Seven cases of autoimmune thyroiditis associated with clinical hyperthyroidism have been published to date. In the case reported here a 35-year-old female patient with AML of the M2 subtype received unmanipulated PBSC from her HLA-identical sister who had therapeutically controlled Graves' disease. Antithyroid antibodies, including thyrotropin receptor (TSHR) antibodies, appeared 1 year after transplant. Clinical hyperthyroidism requiring thyrostatic medication appeared after 2 years. The biological and clinical implications of adoptive, post-transplant autoimmunity are briefly discussed.
DOI10.1038/sj.bmt.1701760
Notify Library Reference ID169

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