|Title||Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Tamura A, Shimizu Y, Tanaka T, Kuroda K, Arakawa Y, Takahashi K, Mishiro S, Shimizu K, Moriyama M|
|Pagination||113 - 120|
|Keywords||Hepatitis E virus, persistent infection, transfusion-transmitted hepatitis E|
Aim: With advent of reverse-transcription (RT)/polymerase chain reaction (PCR) for detection of the hepatitis E viral genome, we carried out retrospective examinations., Methods: Serum samples collected from 68 patients diagnosed as viral hepatitis with unknown etiology were tested for viral markers of hepatitis virus., Results: Two of them were found positive for hepatitis E viral RNA. While the clinical course of one patient (patient 1) was typical as acute hepatitis E, another patient (patient 2) was persistently infected with HEV. Patient 2 was infected with the virus via blood transfusion during chemotherapy against T-cell lymphoma. The entire viral genome from the donor was identical with that from the serum of patient 2 obtained on day 170 after the transfusion of the implicated red blood cell (RBC) product, confirming the transmission of HEV by transfusion. The patient remained negative for anti-HEV antibodies for the follow-up period of six months, probably due to immune suppression by lymphoma and chemotherapy., Conclusion: We report here an unusual case of long-term HEV infection in a patient with T-cell lymphoma. Persistent infection with HEV was probably due to the absence of anti-HEV antibodies, which was caused by lymphoma and chemotherapy., Copyright (C) 2007 Blackwell Publishing Ltd.
|Notify Library Reference ID||4073|