Acute hemolytic transfusion reaction secondary to anti-Fy3.

TitleAcute hemolytic transfusion reaction secondary to anti-Fy3.
Publication TypeJournal Article
Year of Publication2005
AuthorsOlteanu H, Gerber D, Partridge K, Sarode R
JournalImmunohematology / American Red Cross//IMMUNOHEMATOLOGY
Pagination48 - 52
Date Published2005
ISBN Number0894-203X
Other Numbers8806387
Keywords*Blood Transfusion/ae [Adverse Effects], *Hemolysis/im [Immunology], *Isoantibodies/bl [Blood], Acute Disease, Aged, Aged, 80 and over, Female, Humans, Isoantibodies/im [Immunology], Phenotype

A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hab 7 g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1 g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with and LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease.

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