Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation.

TitleTransfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation.
Publication TypeJournal Article
Year of Publication1997
AuthorsKishimoto Y, Yamamoto Y, Ito T, Matsumoto N, Ichiyoshi H, Katsurada T, Date M, Ohga S, Kitajima H, Ikehara S, Fukuhara S
JournalBone marrow transplantation//Bone Marrow Transplant
Volume19
Issue10
Pagination1041 - 3
Date Published1997
ISBN Number0268-3369
Other Numbersbon, 8702459
Keywords*Bone Marrow Transplantation/ae [Adverse Effects], *Psoriasis/th [Therapy], *Thyroiditis, Autoimmune/et [Etiology], Adoptive Transfer, Adult, Female, Humans, Leukemia, Myeloid, Acute/co [Complications], Leukemia, Myeloid, Acute/th [Therapy], Male, Psoriasis/co [Complications], Tissue Donors, Transplantation, Homologous
Abstract

We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.
Notify Library Reference ID4353

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