Cross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor.

TitleCross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor.
Publication TypeJournal Article
Year of Publication2014
AuthorsGiani T, Conte V, Mandala S, D'Andrea MM, Luzzaro F, Conaldi PG, Grossi P, Rossolini GM
JournalJournal of clinical microbiology// J Clin Microbiol
Volume52
Issue7
Pagination2702 - 5
Date Published2014//
ISBN Number1098-660X
Other Numbershsh, 7505564
Keywords*Bacteremia/di [Diagnosis], *beta-Lactamases/se [Secretion], *Cross Infection/di [Diagnosis], *Drug Resistance, Multiple, Bacterial, *Klebsiella Infections/di [Diagnosis], *Klebsiella pneumoniae/de [Drug Effects], *Klebsiella pneumoniae/en [Enzymology], Adult, Humans, Klebsiella pneumoniae/ip [Isolation & Purification], Middle Aged, Transplant Recipients, Transplantation/ae [Adverse Effects], Transplants
Abstract

We describe two cases of bacteremic infections caused by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase that occurred in two solid organ transplant (liver and kidney) recipients, which was apparently transmitted with the allografts. This finding underscores the risk of donor-derived infections by multidrug-resistant Gram-negative pathogens in solid organ transplant recipients and emphasizes the need for rapid screening of organ donors for carriage of similar pathogens. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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